Pyridazines and derivatives

Aromatic organic compounds consist of an aromatic six-membered ring containing two adjacent nitrogen atoms and four carbon atoms; includes compounds derived from pyridazines.

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Aobchem AOBCHEM

5000929780 2-ETHOXY-5-ISOPROPYLPHENYL TR

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227

Apexbio Technology LLC Phthalazinone pyrazole 880487-62-7 5mg

Phthalazinone pyrazole (CAS 880487-62-7) is a potent selective and orally bioavailable inhibitor of Aurora-A kinase a member of the Aurora kinase family that regulates key processes in cell division Dysregulation of Aurora-A is linked to chromosomal instability and oncogenesis in various tumor types In vitro phthalazinone pyrazole demonstrates strong inhibition of Aurora-A kinase activity with an IC50 of 31 nM while showing minimal effect on Aurora-B kinase at concentrations up to 100 M It inhibits the proliferation of HCT116 Colo205 and MCF-7 cells with IC50 values of 7 8 2 9 and 1 6 M respectively This compound is utilized in research to investigate the role of Aurora-A in cell cycle regulation and cancer biology